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« on: June 05, 2008, 04:20:05 PM »
Bit-
Thanks for the reference. It will take me a few days to go over it, but I will go over it. The paper also has some interesting citations (no pun intended) that I will also get a look at. On first glance, it looks like a well-written paper. The main premise is that mtDNA, being responsible for some genes involved in respiration, may be responsible for female-dominated stamina traits. But given that there are literally hundreds of genes involved in these processes, the influence of other chromosomes is likely much larger. Nonetheless, without having examined it in detail I\'ll withold judgment.
While the paper does make it possible for someone with the right lab tools to examine the genotype (the actual DNA sequence) of these genes, unless you have a piece of Better Than Honour\'s DNA (virtually any tissue, or in the case of mtDNA, hair would work), it would be impossible to determine a genotype. Perhaps you could genotype by descent, but that would assume that you had the DNA sequences of his parents. I am interested in this area, and I do have a lab capable of this kind of work. But the biggest hurdle is to identify naturally occurring genetic variants that confer advantages at different race distances. I do, in fact, believe that this is possible. We already know some of the genes involved. Regarding the current discussion, few of them are mitochondrial. But clearly it would be possible to identify breeding stock and progeny with advantageous genotypes. But the critical factor is knowing which genes to examine, and perservering and being lucky enough to find a variant that really matters.
All that being said, remember that genetics is only part of racing ability. Think of it as genetics just providing a basis- a predisposition. Environmental factors are likely as important- things like maternal care, early experiences, injuries, just about everything that goes into bringing an animal to the races. I am sure you can name many full sibs to great horses but were lousy racehorses. There is still an element of chance in it all.