i don\'t know enough about genetically gifted weight lifters vs chemically created weight lifters, too be honest...i was kind of under the impression they were all chemically created. weight lifting, i believe, is mostly anaerobic, not aerobic--but it would still have a performance ceiling too--you run out of fuel pretty quickly in anaerobic activities and risk tearing your muscles if you push it, which is why steroids would be so helpful, they speed up muscle recovery and repair, which would allow them to keep building on the size of their muscles...but this is all a guess...i really have no idea how weight lifting works =)
aerobic performance is capped by red blood cell count, it can\'t go much over 50% without stopping your heart; and by the ability buffer lactic acid and process glucose efficiently--there are drugs that increase these last two capabilities, but even so if you go to far, you\'ll end up tearing your muscles. pain and fatigue are the body\'s way of stopping you before this happens.this is why more efficient oxygen metabolism is such a game changer--you can go a lot farther before you have to switch over to glycolosis and before lactic acid starts eating away at your muscles.
genetically gifted human athletes are born with naturally high red blood cell counts, usually around 46-48%--compare this to lance armstrong, who was tested at just 39%. naturally gifted athletes also have higher lactic acid thresholds and can go farther aerobically before they have switch to anaerobic glycolosis to fuel their muscles--once that happens they have something like 10 seconds more of energy before they are kaput. and for whatever reason, people with naturally high blood cells counts just don\'t seem don\'t respond as well to EPO.
with race horses, the difference between front runners and closers,is that front runners exhaust their oxygen early and have to hope they have gotten far enough to make it across the line before their glycoloic fuel runs out. closers conserve their oxygen early, and hope that they have enough speed to use that saved oxygen to catch and pass the front runners before they switch over to glycolosis and hit the wall. the truth is the speed always collapses, but if they have a big enough lead, it doesn\'t matter. this is why i have never understood the obsession with rating. front runners are never going to switch over to closers, so all you do is take away their advantage.
disclosure: i\'m not a dr or a vet =)