Ok, so I got the bums rush from Maylin\'s office but was sent info on lectures by Dr.Maylin, whom they claim is world renounded on the subject of EPO and many areas of drug testing for over 40 years.My contact info was left, so if/when I get a call back,will ask about administering EPO(or anything in the interval JB said its being done)It seems that question is addressed in here.More than one vet I know for a long time said anything outside of an 8 hour window has substantially less potency, if any at all, as it relates to enhancing performance.
From the session,said to be more than 5years ago:
Question:
Can you tell us briefly in laymans terms about your test for EPO?
Dr. Maylin:
EPO has been with us since 1985. That is when I first heard about it. It is a very difficult drug to do, as you know, it�s a normal hormone produced by the kidney for hypoxia or lack of oxygen. For whatever reason, the kidney gets a signal to send out a hormone to the bone marrow that will make red blood cells. This was really going to be the savior for things like sickle cell anemia and kidney disease in human medicine. Of course, it looked so good it became an equine drug. Even though there is absolutely no reason to think that it is going to do a racehorse any good, because horses dump their spleen and have all the red blood cells they need. If you inject EPO, which is a recombinant human protein, into a horse, it thinks it is a foreign protein or a virus and it develops an antibody. The antibody reacts against the foreign invader, recombinant human EPO, and it also takes out the horses own EPO. So an antibody is developed.
You can get very severe anemia as a result of it and horses can�t race, don�t race well, or die. We knew there was an antibody being produced and it was a very simple solution of doing the conventional antigen/antibody test, just like the coggins test. The coggins test picks up a virus, while ours picks up the so-called drug EPO. We reasoned that if a horse has an EPO antibody, it�s a sick horse. It may not look sick on its face, but it is taking out its own red blood cells. We, with the help of the Racing and Wagering Board in New York, decided that we would put these horses with a high antibody count on the vet�s list and they would not be allowed to race until such time that they were back to soundness again.
We had, at one track, an incidence of three percent reactivity on this test, and when the test was announced it disappeared. Those horses did not race. We virtually have no EPO responders now in New York. We have a couple of horses, I�d say of fifteen thousand tests since the test went into effect, we have had three horses, one was the same horse twice. So it has been a very effective, very inexpensive test and I recognize that it not a gold standard of identification. It�s an antibody/antigen test, but I reason that if it is good enough for a coggins test, the same technology is good enough for an EPO test.
The antibody can last as much as three or four months, so it is quite conceivable that when a horse tests positive there have been two or three trainers involved before the guy who actually did it. So this way the current trainer is not hung out to dry.